Treatment of solid tumor with autologous natural killer cells in mouse models
نویسندگان
چکیده
منابع مشابه
Treatment of solid tumor with autologous natural killer cells in mouse models
Cancer immunosurveillance protects the host from outgrowth of tumor cells. Natural killer (NK) cell function positively associates with reduction of cancer risk and with better survival of gastrointestinal stromal tumor patients. We expanded murine NK cells and characterized their anti-tumor activity in vitro and in vivo. Adoptive transfer of the expanded NK cells into tumor-bearing mice reduce...
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Our results show that using an EBV-LCL feeder cell line, large numbers of pure populations of highly activated NK cells can be expanded ex vivo under GMP conditions. With the exception of thyroiditis and constitutional symptoms related to IL-2 therapy, infusions of up to 1 x 10(8) cells/kg of ex vivo expanded NK have been well tolerated and have provided preliminary clinical evidence for mediat...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2014
ISSN: 2051-1426
DOI: 10.1186/2051-1426-2-s3-p23